This cross-cultural study investigates wisdom in people with high functioning autism (HFA). The diagnostic characteristics of autism are universal, as manifest in particular outward behaviours (DSM-4). One of the aims of this study is to explore how wisdom is understood in people with HFA. In a mixed methods study, interview questions asked participants how they understand wisdom; self-report measures of well-being (Life Satisfaction Scale) and wisdom (the 3D Wisdom Scale and the Adult Self-Transcendence Inventory) were also administered. Forty-six males participated from Karachi, Pakistan, and the Greater Toronto Area (GTA), Canada; the half diagnosed with high functioning autism were matched [...]