This study investigated the influence of HR policies and practices on the motivation of employees in private schools. Relevant information was gathered from school teachers in Karachi through a questionnaire while the sample size includes 512 responses. The statistical tool applied in this study was partial least square structural equation model (PLS- SEM). Findings showed that compensation, employee empowerment, fair job appraisal, employee recognition and job satisfaction have a positive and significant relationship with the employee motivation concluding that these factors of HR policies motivate employees. This study provided management with the ways to incorporate strategies in order to motivate their employees.